MODELING TARGETED IVERMECTIN TREATMENT FOR CONTROLLING RIVER BLINDNESS
نویسندگان
چکیده
منابع مشابه
Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness
Background Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca volvulus. A single ivermectin (standard) dose clears the skin-dwelling microfilarial progeny of adult worms (macrofilariae) and temporarily impedes the...
متن کاملControl, Elimination, and Eradication of River Blindness: Scenarios, Timelines, and Ivermectin Treatment Needs in Africa
River blindness (onchocerciasis) causes severe itching, skin lesions, and vision impairment including blindness. More than 99% of all current cases are found in sub-Saharan Africa. Fortunately, vector control and community-directed treatment with ivermectin have significantly reduced morbidity. Studies in Mali and Senegal proved the feasibility of elimination with ivermectin administration. The...
متن کاملCorrection: Control, Elimination, and Eradication of River Blindness: Scenarios, Timelines, and Ivermectin Treatment Needs in Africa
There is an error in the antepenultimate sentence of the abstract. The number of treatments is incorrect. The correct sentence is: The control scenario requires community-directed treatment with ivermectin beyond 2045 with around 2.63 billion treatments over 2013–2045; the elimination scenario, until 2028 in areas where feasible, but beyond 2045 in countries with operational challenges, around ...
متن کاملIdentifying sub-optimal responses to ivermectin in the treatment of River Blindness.
Identification of drug resistance before it becomes a public health concern requires a clear distinction between what constitutes a normal and a suboptimal treatment response. A novel method of analyzing drug efficacy studies in human helminthiases is proposed and used to investigate recent claims of atypical responses to ivermectin in the treatment of River Blindness. The variability in the ra...
متن کاملCase 7: Controlling Onchocerciasis (River Blindness) in Sub-Saharan Africa
The first draft of this case was prepared by Jane Seymour and Molly Kinder; significant contributions to the current version were made by Bruce Benton. as in a prominent square in Ouagadougou, Burkina Faso, visitors see a distinctive statue of a child leading a blind man—a symbolic reminder to passersby of the part each partner played in the control of one of Africa’s most devastating diseases....
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ژورنال
عنوان ژورنال: The American Journal of Tropical Medicine and Hygiene
سال: 2006
ISSN: 0002-9637,1476-1645
DOI: 10.4269/ajtmh.2006.75.921